Description

Clemastine Fumarate USP

Clemastine Fumarate USP is a high-purity first-generation antihistamine used in pharmaceutical formulations for the treatment of allergic conditions. Compliant with United States Pharmacopeia (USP) standards, it is widely utilized in oral and injectable dosage forms for relief of allergic rhinitis, urticaria, and other histamine-mediated symptoms.
Clemastine Fumarate is chemically designated as (R)-2-[2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine Fumarate. It appears as a white to off-white crystalline powder that is slightly soluble in water and soluble in alcohol, supporting formulation into tablets, syrups, and injectable preparations.
In pharmaceutical and research applications, Clemastine Fumarate USP is used in:
• Oral formulations for allergy symptom relief
• Treatment of allergic rhinitis and urticaria
• Injectable preparations for acute allergic reactions
• Antihistamine and sedative research applications
• Studies involving histamine receptor antagonism
• Development of allergy and immunology therapies
Clemastine Fumarate USP functions as a selective H1-Receptor antagonist, blocking histamine-mediated effects such as vasodilation, increased vascular permeability, and itching. As a first-generation antihistamine, it also exhibits central nervous system penetration, contributing to sedative effects.
CarboMer supplies Clemastine Fumarate USP with defined assay, impurity profile, and physicochemical characteristics suitable for regulated pharmaceutical manufacturing and formulation development.
The material meets USP monograph specifications and is appropriate for controlled pharmaceutical production environments.
The material is packaged in sealed, moisture-resistant, tamper-evident containers and protected from excessive light to preserve stability and handling quality. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity, assay, impurity profile, water content, and related substances where applicable. Technical support is available to assist with formulation development, stability considerations, and regulatory alignment.
As with all CarboMer supplied active pharmaceutical ingredients, Clemastine Fumarate USP is supported by dependable global supply, rigorous quality systems, and expert technical guidance to ensure consistent and reliable performance across pharmaceutical applications.