Description

Cis-Atracurium Besylate

Cis-Atracurium Besylate is a high-purity nondepolarizing neuromuscular blocking agent used in pharmaceutical formulations for skeletal muscle relaxation during surgical and critical care procedures. It is the 1R-cis-1′R-cis isomer of Atracurium and is recognized for its predictable pharmacokinetics and organ-independent elimination profile.
Cis-Atracurium Besylate appears as a white to off-white powder that is soluble in water, allowing formulation into sterile injectable dosage forms. It undergoes Hofmann elimination at physiological pH and temperature, resulting in degradation independent of renal or hepatic function.
In pharmaceutical and clinical applications, Cis-Atracurium Besylate is used in:
• Intravenous formulations for surgical muscle relaxation
• Facilitation of endotracheal intubation
• Management of mechanically ventilated patients
• Critical care sedation protocols requiring neuromuscular blockade
• Research involving neuromuscular transmission and receptor pharmacology
• Pharmacokinetic and stability studies
Cis-Atracurium Besylate functions by competitively binding to nicotinic acetylcholine receptors at the neuromuscular junction, preventing acetylcholine-mediated depolarization and resulting in temporary muscle paralysis.
CarboMer supplies Cis-Atracurium Besylate with defined assay, impurity profile, stereochemical integrity, and microbiological quality suitable for regulated pharmaceutical development and manufacturing.
The material is packaged in sealed, moisture-resistant, tamper-evident containers and protected from excessive light to preserve stability. Available in laboratory and pilot-scale quantities. Documentation includes Certificate Of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity, assay, stereochemical purity, impurity profile, water content, and microbial limits. Technical support is available to assist with formulation considerations and regulatory alignment.
As with all CarboMer supplied active pharmaceutical ingredients, Cis-Atracurium Besylate is supported by dependable global supply, rigorous quality systems, and expert technical guidance to ensure consistent and reliable pharmaceutical product development.