Description

Cinnarizine EP/USP

Cinnarizine EP/USP is a high-purity calcium channel antagonist with antihistaminic properties used in pharmaceutical formulations for the management of vertigo, motion sickness, and vestibular disorders. Compliant with European Pharmacopoeia (EP) and United States Pharmacopeia (USP) standards, it is widely utilized in oral dosage forms for neurological and balance-related conditions.
Cinnarizine is chemically designated as 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine. It appears as a white to off-white crystalline powder that is practically insoluble in water and soluble in organic solvents, making it suitable for formulation into tablets and capsules.
In pharmaceutical and research applications, Cinnarizine EP/USP is used in:
• Oral formulations for treatment of vertigo and vestibular disorders
• Motion sickness prevention and management
• Peripheral vascular disorder therapies
• Antihistaminic and antiemetic research applications
• Studies involving calcium channel modulation
• Development of central nervous system therapeutic agents
Cinnarizine EP/USP functions by inhibiting calcium influx into smooth muscle cells and vestibular sensory cells, leading to reduced vasoconstriction and stabilization of inner ear function. Its antihistaminic activity further contributes to its effectiveness in controlling motion-related symptoms.
CarboMer supplies Cinnarizine EP/USP with defined assay, impurity profile, and physicochemical characteristics suitable for regulated pharmaceutical manufacturing and formulation development.
The material meets EP and USP monograph specifications and is appropriate for controlled pharmaceutical production environments.
The material is packaged in sealed, moisture-resistant, tamper-evident containers and protected from excessive light to preserve stability and handling quality. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity, assay, impurity profile, water content, and related substances where applicable. Technical support is available to assist with formulation development, stability considerations, and regulatory alignment.
As with all CarboMer supplied active pharmaceutical ingredients, Cinnarizine EP/USP is supported by dependable global supply, rigorous quality systems, and expert technical guidance to ensure consistent and reliable performance across pharmaceutical applications.