Description

Cholecalciferol USP

Cholecalciferol USP is a high-purity form of Vitamin D3 used in pharmaceutical, nutraceutical, and fortified food formulations to support calcium absorption, bone health, immune function, and endocrine balance. Compliant with United States Pharmacopeia (USP) standards, it is widely incorporated into oral dosage forms, dietary supplements, and clinical nutrition products requiring precisely controlled potency.
Cholecalciferol is chemically designated as (3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol. It appears as a white to off-white crystalline powder or as a stabilized oily form, depending on the concentration and formulation grade. It is soluble in fats and organic solvents but insoluble in water, requiring encapsulation or dispersion systems for optimal bioavailability.
In pharmaceutical, nutritional, and food applications, Cholecalciferol USP is used in:
• Oral tablets, capsules, softgels, and liquid drops for Vitamin D supplementation
• Fortified food and beverage products
• Pediatric and adult clinical nutrition formulations
• Combination bone-health formulations with calcium, magnesium, and Vitamin K
• Injectable and high-potency preparations for deficiency correction
• Research involving metabolic regulation of Vitamin D pathways
Cholecalciferol USP functions by converting to Calcidiol in the liver and subsequently to calcitriol, the biologically active form of Vitamin D, in the kidneys. It plays an essential role in regulating calcium and phosphorus homeostasis, supporting healthy bone mineralization and contributing to immunological and cellular functions.
CarboMer supplies Cholecalciferol USP with control over potency (IU per gram), purity, oxidation markers, residual solvents, and microbial limits. Material meets USP monograph specifications and is suitable for regulated manufacturing environments that require precise dosage control.
The material is packaged in sealed, light-resistant, oxygen-protective, tamper-evident containers to ensure maximum stability. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity (UV, IR), assay (potency in IU/g), specific rotation, residual solvents, peroxide value, and microbial purity. CarboMer provides formulation guidance to support effective incorporation into solid, liquid, and lipid-based delivery systems.
As with all CarboMer fat-soluble vitamins, Cholecalciferol USP is supported by dependable global supply, rigorous quality control, and expert formulation assistance to ensure safe, effective, and high-quality product development.