Description

Chlorpromazine Hydrochloride USP

Chlorpromazine Hydrochloride USP is a high-purity phenothiazine antipsychotic used in pharmaceutical formulations for the management of schizophrenia, acute psychosis, severe behavioral disturbances, and nausea and vomiting. Compliant with United States Pharmacopeia (USP) standards, it is one of the earliest and most well-established antipsychotic agents, offering broad therapeutic applications in psychiatry and acute care.
Chlorpromazine Hydrochloride is chemically designated as 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine monohydrochloride. It appears as a white to faintly yellow crystalline powder that is freely soluble in water and alcohol, providing versatility for oral, injectable, and compounded dosage forms.
In pharmaceutical applications, Chlorpromazine Hydrochloride USP is used in:
• Oral tablets and capsules for chronic psychiatric management
• Injectable formulations for acute agitation, psychosis, and severe nausea
• Suppositories and liquid preparations for non-oral administration
• Combination therapies for treatment-resistant psychiatric conditions
• Research involving dopamine receptor antagonists and neuroleptic mechanisms
Chlorpromazine Hydrochloride USP acts primarily as a Dopamine D2-receptor antagonist, reducing dopaminergic signaling in the central nervous system. It also exhibits antihistaminic, anticholinergic, and antiadrenergic effects, contributing to its sedative and antiemetic properties. Its broad receptor profile gives it utility in psychiatric, gastrointestinal, and perioperative settings.
CarboMer supplies Chlorpromazine Hydrochloride USP with control over assay, purity, residual solvents, particle size, and microbial content. The material meets USP monograph requirements and is suitable for regulated pharmaceutical development and commercial manufacturing.
The material is packaged in sealed, moisture-protective, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity (IR, HPLC), assay on anhydrous basis, melting range, water content, residual solvents, and microbial limits. CarboMer provides formulation support to ensure optimal performance in oral, parenteral, and alternative dosage forms.
As with all CarboMer central nervous system APIs, Chlorpromazine Hydrochloride USP is backed by reliable global supply, stringent quality control, and expert regulatory assistance to support safe, effective, and compliant pharmaceutical product development.