Description

Chlorphenamine Maleate USP

Chlorphenamine Maleate USP is a high-purity antihistamine used in pharmaceutical formulations for the treatment of allergic conditions, including allergic rhinitis, urticaria, conjunctivitis, and mild allergic reactions. Compliant with United States Pharmacopeia (USP) standards, it is widely used in oral solid, liquid, and combination cold and allergy products.
Chlorphenamine Maleate is chemically designated as (±)-3-(4-Chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine maleate. It appears as a white to off-white crystalline powder that is freely soluble in water and alcohol, providing flexibility for both solution-based and solid dosage manufacturing.
In pharmaceutical applications, Chlorphenamine Maleate USP is used in:
• Oral tablets and capsules for allergy relief
• Liquid syrups and solutions for pediatric and adult formulations
• Combination cold, cough, and allergy products
• Topical formulations requiring antihistaminic action
• Research involving H1-receptor antagonists and allergic response mechanisms
Chlorphenamine Maleate USP acts as a selective H1-antihistamine, reducing the effects of endogenous Histamine by competitively inhibiting receptor binding. It helps alleviate sneezing, itching, rhinorrhea, watery eyes, and other histamine-mediated symptoms. Its mild anticholinergic and sedative properties contribute to its therapeutic effect, particularly in nighttime formulations.
CarboMer supplies Chlorphenamine Maleate USP with control over assay, purity, residual solvents, optical rotation, and microbial content. Material meets USP monograph specifications and is suitable for regulated pharmaceutical manufacturing.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory, pilot, and commercial-scale volumes. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability data.
Each batch is tested for identity (IR, HPLC), assay on anhydrous basis, melting range, residual solvents, loss on drying, and microbial limits. CarboMer provides formulation guidance and technical support to ensure optimal integration into allergy, cold, and combination drug products.
As with all CarboMer active pharmaceutical ingredients, Chlorphenamine Maleate USP is backed by dependable global supply, rigorous quality assurance, and expert regulatory support to ensure safe, effective, and consistent pharmaceutical product development.