Description

Chlorobutanol, Anhydrous, NF

Chlorobutanol, Anhydrous, NF is a high-purity preservative and antimicrobial agent used in pharmaceutical, ophthalmic, cosmetic, and injectable formulations. Compliant with National Formulary (NF) standards, it provides broad-spectrum antimicrobial activity and is commonly incorporated into multi-dose containers requiring long-term stability and microbial protection.
Chlorobutanol is chemically designated as 1,1,1-Trichloro-2-methyl-2-propanol. It appears as white crystalline granules or powder with a characteristic odor, and it is soluble in alcohols, essential oils, and slightly soluble in water. Its stability is optimal under cool, dry storage conditions.
In pharmaceutical and personal care applications, Chlorobutanol, Anhydrous, NF is used in:
• Ophthalmic solutions and suspensions requiring antimicrobial preservation
• Parenteral preparations and injectable formulations
• Topical creams, gels, and ointments
• Oral rinses and dental preparations
• Cosmetics and skin care products requiring controlled microbial protection
• Multi-dose packaging systems including eye drops and nasal sprays
Chlorobutanol functions by disrupting microbial cell membrane integrity, offering preservative efficacy at relatively low concentrations. It is valued for its compatibility with a wide range of excipients and active ingredients, as well as its low reactivity in aqueous and semi-aqueous formulations.
CarboMer supplies Chlorobutanol, Anhydrous, NF with control over assay, melting range, purity, residual solvents, and microbial content. The material meets NF monograph specifications and is suitable for regulated pharmaceutical and personal care product manufacturing.
The material is packaged in sealed, moisture-resistant, tamper-evident containers to preserve stability. Available in laboratory, pilot, and commercial-scale volumes. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity (IR), assay, melting point, loss on drying, residual solvents, and microbial limits. CarboMer provides formulation guidance to ensure proper incorporation and preservation performance in multi-dose systems.
As with all CarboMer excipients and antimicrobial ingredients, Chlorobutanol, Anhydrous, NF is backed by consistent supply, rigorous quality control, and technical expertise to support safe, effective, and compliant product development.