Description

Cetirizine HCl

Cetirizine HCl is a high-purity second-generation antihistamine used in pharmaceutical formulations for the treatment of allergic conditions. It is widely utilized in oral dosage forms for relief of symptoms associated with allergic rhinitis and chronic urticaria, offering effective H1-receptor antagonism with minimal sedative effects.
Cetirizine HCl is chemically designated as (±)-[2-[4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazinyl]Ethoxy]Acetic Acid Dihydrochloride. It appears as a white to off-white crystalline powder that is freely soluble in water and suitable for formulation into tablets, syrups, and oral solutions.
In pharmaceutical and research applications, Cetirizine HCl is used in:
• Oral tablets and liquid formulations for allergy relief
• Treatment of seasonal and perennial allergic rhinitis
• Management of chronic idiopathic urticaria
• Pediatric and adult antihistamine products
• Research involving histamine receptor activity
• Development of non-sedating antihistamine therapies
Cetirizine HCl functions as a selective peripheral H1-receptor antagonist, blocking histamine-mediated responses such as itching, swelling, and vasodilation. Its reduced penetration of the blood–brain barrier contributes to a lower incidence of sedation compared to first-generation antihistamines.
CarboMer supplies Cetirizine HCl with defined assay, impurity profile, and physicochemical characteristics suitable for regulated pharmaceutical manufacturing and formulation development.
The material is packaged in sealed, moisture-resistant, tamper-evident containers and protected from excessive light to preserve stability and handling quality. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity, assay, impurity profile, water content, and related substances where applicable. Technical support is available to assist with formulation development, stability considerations, and regulatory alignment.
As with all CarboMer supplied active pharmaceutical ingredients, Cetirizine HCl is supported by dependable global supply, rigorous quality systems, and expert technical guidance to ensure consistent and reliable performance across pharmaceutical applications.