Description

Carboxymethyl-β-Cyclodextrin

Carboxymethyl-β-Cyclodextrin is a high-purity, water-soluble β-Cyclodextrin derivative used in pharmaceutical, nutraceutical, and cosmetic formulations to improve solubility, stability, and bioavailability of active ingredients. Through controlled carboxymethylation of β-Cyclodextrin, the molecule gains enhanced hydrophilicity and stronger inclusion-complex formation capability, making it highly effective for solubilizing hydrophobic drugs.
Carboxymethyl-β-Cyclodextrin appears as a white to off-white hygroscopic powder that dissolves readily in water to form clear solutions. Its anionic character contributes to improved complexation efficiency, reduced aggregation, and better compatibility in aqueous and semi-aqueous formulations.
In pharmaceutical, cosmetic, and personal care applications, Carboxymethyl-β-Cyclodextrin is used in:
• Solubilization of poorly water-soluble active pharmaceutical ingredients
• Stabilization of volatile, photosensitive, or oxidation-prone molecules
• Oral, injectable, ophthalmic, and topical formulations
• Transdermal and mucosal delivery systems requiring enhanced permeation
• Flavor masking and odor-reduction applications in nutraceuticals
• Cosmetic formulations for fragrance stabilization and improved sensory attributes
Carboxymethyl-β-Cyclodextrin enhances formulation performance by forming inclusion complexes that improve dissolution rate, chemical stability, and bioavailability of active ingredients. Its modified structure provides greater solubility than native β-Cyclodextrin, expanding its use into aqueous-intensive dosage forms and systems requiring rapid dispersion.
CarboMer supplies Carboxymethyl-β-Cyclodextrin with control over degree of substitution, molecular weight distribution, solubility, purity, and microbial content. The material is produced under stringent quality systems and is suitable for regulated pharmaceutical and personal care applications.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity (IR), degree of substitution, purity, pH, moisture content, and microbial limits. CarboMer provides formulation support to ensure optimal performance in solubilization, stabilization, and controlled-delivery systems.
As with all CarboMer Cyclodextrin derivatives, Carboxymethyl-β-Cyclodextrin is supported by reliable global supply, rigorous quality assurance, and technical expertise to ensure safe, effective, and high-performance product development.