Description

Carboxymethyl α-Cyclodextrin

Carboxymethyl α-Cyclodextrin is a high-purity chemically modified cyclodextrin derivative used in pharmaceutical, biomedical, and research applications for enhanced solubility, ionic interaction, and functional inclusion complexation. The introduction of Carboxymethyl groups imparts anionic character and significantly improves aqueous solubility compared to native α-Cyclodextrin.
Carboxymethyl α-Cyclodextrin appears as a white to off-white amorphous powder that is freely soluble in water, forming clear to slightly opalescent solutions. The Cyclodextrin cavity retains its ability to form inclusion complexes with hydrophobic molecules, while the Carboxymethyl substitution enables additional electrostatic interactions with cationic compounds and biological systems.
In pharmaceutical and research applications, Carboxymethyl α-Cyclodextrin is used in:
• Solubility enhancement of poorly water-soluble active ingredients
• Ionic complexation with basic and cationic molecules
• Drug delivery systems including oral, topical, and parenteral formulations
• Stabilization of labile compounds against degradation
• Controlled-release and targeted delivery research
• Studies involving host–guest chemistry and supramolecular systems
Carboxymethyl α-Cyclodextrin functions by combining the inclusion capability of α-Cyclodextrin with an anionic exterior that supports improved interaction, dispersion, and compatibility in aqueous environments. This dual functionality allows improved formulation performance without chemical modification of the active ingredient.
CarboMer supplies Carboxymethyl α-Cyclodextrin with defined degree of substitution, consistent molecular characteristics, and high purity suitable for regulated pharmaceutical research and advanced formulation development.
The material is packaged in sealed, moisture-resistant, tamper-evident containers to preserve stability and handling quality. Available in laboratory and pilot-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity, degree of substitution, solubility, moisture content, and purity profile where applicable. Technical support is available to assist with complexation studies, formulation optimization, and application development.
As with all CarboMer supplied cyclodextrin derivatives, Carboxymethyl α-Cyclodextrin is supported by dependable global supply, rigorous quality systems, and expert technical guidance to ensure consistent and reliable performance across pharmaceutical and research applications.