Description

Carboxyethyl β-Cyclodextrin

Carboxyethyl β-Cyclodextrin is a chemically modified Cyclodextrin derivative used in pharmaceutical, biomedical, and research applications to enhance solubility, stability, and ionic interaction of active ingredients. Carboxyethyl substitution introduces an anionic functional group, improving aqueous solubility and enabling electrostatic interactions with cationic molecules while preserving the characteristic inclusion complex capability of β-cyclodextrin.
Carboxyethyl β-Cyclodextrin appears as a white to off-white amorphous powder that is freely soluble in water, forming clear to slightly opalescent solutions. The hydrophobic Cyclodextrin cavity remains available for non-covalent complexation, while the carboxyethyl groups provide improved dispersion and formulation flexibility.
In pharmaceutical and research applications, Carboxyethyl β-Cyclodextrin is used in:
• Solubility enhancement of poorly water-soluble drug substances
• Ionic complexation with basic and cationic active ingredients
• Oral, parenteral, ophthalmic, and topical drug delivery systems
• Stabilization of labile compounds against hydrolysis and oxidation
• Controlled-release and targeted delivery research
• Studies involving host–guest chemistry and cyclodextrin-based systems
Carboxyethyl β-Cyclodextrin functions by forming inclusion complexes that increase apparent solubility and dissolution rate while the anionic exterior supports improved compatibility with charged drug molecules. This dual functionality supports enhanced formulation stability without chemical modification of the active ingredient.
CarboMer supplies Carboxyethyl β-Cyclodextrin with defined substitution characteristics, consistent molecular properties, and high purity suitable for regulated pharmaceutical research and advanced formulation development.
The material is packaged in sealed, moisture-resistant, tamper-evident containers to preserve stability and performance. Available in laboratory and pilot-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity, degree of substitution, solubility, moisture content, ionic content, and microbial limits. Technical support is available to assist with complexation studies, formulation optimization, and application development.
As with all CarboMer supplied Cyclodextrin derivatives, Carboxyethyl β-Cyclodextrin is supported by dependable global supply, rigorous quality systems, and expert technical guidance to ensure consistent and reliable performance across pharmaceutical and research applications.