Description

Benzalkonium Chloride USP

Benzalkonium Chloride USP is a high-purity quaternary ammonium compound used as an antimicrobial preservative, surfactant, and disinfectant in a wide range of pharmaceutical and ophthalmic formulations. It provides broad-spectrum activity against bacteria, fungi, and viruses, ensuring the microbial integrity of multi-dose preparations. Benzalkonium Chloride

• Is a USP-compliant antimicrobial preservative and surfactant
• Is effective against Gram-positive and Gram-negative bacteria, fungi, and enveloped viruses
• Is suitable for ophthalmic, nasal, oral, topical, and veterinary dosage forms
• Is also used in disinfectant solutions and antiseptic products
• Is manufactured under Good Manufacturing Practice (GMP) conditions
• Supplied with complete regulatory documentation including Certificate of Analysis (CoA) and supporting technical data

Chemically, Benzalkonium Chloride is a mixture of Alkylbenzyldimethylammonium chlorides with varying alkyl chain lengths (predominantly C12–C18). It is highly soluble in water and functions as a cationic surfactant, disrupting microbial cell membranes and providing preservative efficacy in aqueous systems.

In pharmaceutical applications, Benzalkonium Chloride USP is used in:

• Ophthalmic solutions and suspensions as a preservative and antimicrobial agent
• Nasal sprays and inhalation solutions to maintain sterility and prolong shelf life
• Topical creams, gels, and antiseptic washes for skin disinfection and wound care
• Oral and dental formulations including mouthwashes and lozenges
• Veterinary preparations and medicated disinfectants

Benzalkonium Chloride is highly effective at low concentrations (typically 0.004%–0.02%), providing a balance of antimicrobial protection and formulation compatibility. Its cationic surfactant properties can impact protein stability or surface interactions, so formulators should evaluate compatibility with active ingredients and excipients.

CarboMer supplies Benzalkonium Chloride USP with tight control over alkyl distribution, assay, and impurity profile. The material meets USP monograph specifications to ensure reproducibility and compliance in regulated products.

The material is packaged in sealed, tamper-evident containers appropriate for safe handling and storage. Available in research, pilot, and commercial-scale quantities. Minimum order quantities (MOQ), lead times, and full regulatory documentation are provided upon request.

Each batch is tested for identification, assay, alkyl distribution, pH, residual solvents, and microbial limits. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability accompany every shipment.

As with all CarboMer excipients and functional actives, Benzalkonium Chloride USP is supported by technical formulation guidance, regulatory consulting, and reliable supply chain management to help you deliver safe, effective pharmaceutical products to market.