Description

Atorvastatin Calcium

Atorvastatin Calcium is a high-purity lipid-lowering agent used in pharmaceutical formulations for the treatment of hypercholesterolemia and prevention of cardiovascular disease. It is a selective, competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme responsible for the rate-limiting step in cholesterol biosynthesis. Atorvastatin Calcium
• Is a pharmaceutical-grade HMG-CoA reductase inhibitor for oral dosage forms
• Is used to reduce total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol
• Provides effective lipid control and cardiovascular protection
• Is suitable for tablets, capsules, and combination drug formulations
• Is manufactured under Good Manufacturing Practice (GMP) certified conditions
• Is supplied with complete regulatory documentation including Certificate of Analysis (CoA) and technical data
Atorvastatin Calcium is chemically designated as (3R,5R)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt (2:1) trihydrate. It appears as a white to off-white crystalline powder, slightly soluble in water, and freely soluble in methanol and ethanol.
In pharmaceutical applications, Atorvastatin Calcium is used in:
• Oral tablet and capsule formulations for cholesterol management
• Combination therapies with antihypertensive or antiplatelet agents
• Long-term cardiovascular risk reduction and secondary prevention strategies
• Clinical research and development of next-generation lipid-lowering drugs
• Compounded formulations for patient-specific cardiovascular care
Atorvastatin Calcium acts primarily in the liver, reducing intracellular cholesterol synthesis, which increases LDL receptor expression and enhances clearance of LDL from the bloodstream. It has demonstrated efficacy in reducing the risk of myocardial infarction, stroke, and atherosclerotic progression.
CarboMer supplies Atorvastatin Calcium that is characterized by assay, polymorphic form, residual solvents, and microbial purity. The material meets high pharmaceutical standards and is suitable for regulated manufacturing.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. It is available in laboratory, pilot, and commercial-scale volumes. Minimum order quantities (MOQ), lead times, and documentation including CoA and SDS are provided upon request.
Each batch is tested for identity (IR, HPLC), assay (anhydrous basis), water content, particle size, and microbial limits. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation accompany every shipment.
As with all CarboMer cardiovascular APIs, Atorvastatin Calcium is supported by formulation expertise, regulatory compliance assistance, and a reliable global supply chain to ensure safe, effective, and compliant pharmaceutical product performance.