Description

Allopurinol

Allopurinol is a high-purity xanthine oxidase inhibitor used in pharmaceutical formulations for the management of gout and hyperuricemia associated with metabolic disorders or cancer therapy. It reduces uric acid production by inhibiting the enzymatic oxidation of hypoxanthine and xanthine to uric acid, effectively preventing urate crystal formation and deposition. Allopurinol
• Is a pharmaceutical-grade Xanthine oxidase inhibitor for oral formulations
• Is used in the treatment of gout, hyperuricemia, and uric acid nephropathy
• Prevents urate crystal deposition and associated inflammation
• Is sSuitable for tablets, capsules, and combination formulations
• Is manufactured under Good Manufacturing Practice (GMP) certified conditions
• Is supplied with complete regulatory documentation including Certificate of Analysis (CoA) and technical data
Allopurinol is chemically designated as 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one. It appears as a white to off-white crystalline powder, practically insoluble in water but soluble in alkaline solutions, allowing consistent formulation for oral dosage forms.
In pharmaceutical applications, Allopurinol is used in:
• Oral tablets and capsules for chronic gout and hyperuricemia management
• Adjunct therapy during chemotherapy or radiotherapy to prevent tumor lysis-induced uric acid elevation
• Combination formulations with uricosuric agents or anti-inflammatory drugs
• Research and development of novel xanthine oxidase inhibitors
• Clinical formulations addressing renal complications of high uric acid levels
Allopurinol works by competitively inhibiting Xanthine oxidase, reducing uric acid production and increasing the concentration of more soluble precursors, hypoxanthine and xanthine. Its use results in effective long-term control of serum uric acid and prevention of gout flare-ups.
CarboMer supplies Allopurinol that is characterized by assay, polymorphic form, residual solvents, and microbial purity. The material meets pharmaceutical-grade quality standards and is suitable for regulated manufacturing.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. It is available in laboratory, pilot, and commercial-scale volumes. Minimum order quantities (MOQ), lead times, and documentation including CoA and SDS are provided upon request.
Each batch is tested for identity (IR, HPLC), assay (anhydrous basis), residual solvents, water content, and microbial limits. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation accompany every shipment.
As with all CarboMer active pharmaceutical ingredients, Allopurinol is supported by formulation expertise, regulatory compliance assistance, and dependable global supply to ensure safe, effective, and high-quality pharmaceutical product performance.