Description

a-Cyclodextrin polymer

α-Cyclodextrin Polymer is a high-purity, crosslinked cyclic oligosaccharide excipient used in pharmaceutical formulations as a complexing agent, controlled-release matrix former, and solubilizing polymer for poorly water-soluble drugs. Its unique three-dimensional network retains the inclusion capabilities of monomeric cyclodextrin while providing enhanced stability and controlled release characteristics. α-Cyclodextrin Polymer

• Is a pharmaceutical-grade crosslinked α-Cyclodextrin polymer
• Functions as a solubilizer, complexation carrier, and sustained-release matrix
• Is suitable for oral tablets, capsules, suspensions, and topical formulations
• Provides improved physicochemical stability compared to native cyclodextrins
• Is manufactured under Good Manufacturing Practice (GMP) conditions
• Supplied with complete regulatory documentation including Certificate of Analysis (CoA) and supporting technical data

α-Cyclodextrin is composed of six Glucose units linked by α-1,4-glycosidic bonds, forming a toroidal structure with a hydrophobic cavity and hydrophilic outer surface. Crosslinking with appropriate reagents (e.g., epichlorohydrin) yields a water-insoluble or partially soluble polymer with high binding capacity and controlled drug release properties.

In pharmaceutical applications, α-Cyclodextrin Polymer is used in:

• Controlled-release oral dosage forms for sustained delivery of small molecules and peptides
• Taste masking and odor masking formulations by complexing with volatile compounds
• Topical and mucosal dosage forms to enhance solubility and stability of active ingredients
• Solid dispersions and matrix systems for improved bioavailability of poorly soluble APIs

The polymer maintains the ability to form inclusion complexes while reducing dissolution rates, supporting targeted release profiles and reduced burst effects. It is chemically inert and biocompatible, with minimal systemic absorption.

CarboMer supplies α-Cyclodextrin Polymer with tight control over crosslinking density, particle size, residual monomers, and microbial content. The material is produced under GMP-controlled conditions to support formulation development and regulatory submissions.

The product is packaged in sealed, moisture-protected, tamper-evident containers. Available in research, pilot, and commercial-scale quantities. Minimum order quantities (MOQ), lead times, and full technical documentation are provided upon request.

Each batch is tested for identity, assay of bound cyclodextrin, degree of crosslinking, residual solvents, microbial limits, and compliance with internal specifications. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and supporting data accompany each shipment.

As with all CarboMer cyclodextrins and functional excipients, α-Cyclodextrin Polymer is supported by formulation development expertise, regulatory consulting, and reliable global supply to help you bring innovative oral and topical delivery systems to market.