Description

5-trans Latanoprost

5-trans Latanoprost is a high-purity Prostaglandin F2α analogue used as an active pharmaceutical ingredient (API) in ophthalmic formulations for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma and ocular hypertension. This synthetic lipid compound selectively binds prostanoid FP receptors, increasing uveoscleral outflow to lower IOP effectively. 5-trans Latanoprost

• Is a pharmaceutical-grade Prostaglandin analogue API
• Is a potent and selective FP receptor agonist for ocular hypertension treatment
• Is suitable for sterile ophthalmic solutions (eye drops)
• Is supplied as an oil or crystalline solid for formulation under aseptic conditions
• Is manufactured under Good Manufacturing Practice (GMP) conditions
• Is supplied with complete regulatory documentation including Certificate of Analysis (CoA) and supporting technical data

Chemically designated as Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoate, 5-trans Latanoprost differs structurally in the configuration of the double bond compared to conventional (5Z)-Latanoprost. This stereochemical variation is used in research and development for understanding structure-activity relationships, receptor selectivity, and stability in ocular formulations.

In pharmaceutical research and development, 5-trans Latanoprost is used in:

• Investigational ophthalmic therapies for lowering intraocular pressure
• Structure-activity studies comparing potency and receptor binding to standard latanoprost
• Formulation development of novel prostaglandin analogues or combination products
• Analytical reference standard for impurity profiling and stability studies in ophthalmic APIs

Due to its potent pharmacological action, formulation and handling require stringent GMP controls and careful validation of storage and dispensing systems to maintain product stability and sterility.

CarboMer supplies 5-trans Latanoprost with tight specifications for isomeric purity, residual solvents, and related substances to support both research and regulated development. The material is packaged under inert atmosphere in amber glass vials or sealed containers to protect from light and degradation.

Available in research and pilot-scale quantities. Minimum order quantities (MOQ), lead times, and technical documentation including CoA, SDS, and supporting analytical data are provided upon request.

Each batch is tested using validated methods (HPLC, NMR, chiral chromatography) to confirm chemical identity, assay, stereochemical configuration, and impurity profile. All shipments include full traceability documentation.

As with all CarboMer specialty prostaglandins and ophthalmic actives, 5-trans Latanoprost is supported by technical guidance, regulatory consulting, and secure supply chain management to help innovators advance high-quality ocular therapies to market.